PE-22-28 (10mg)

PE-22-28 – Research Peptide
PE-22-28 is a synthetic derivative of spadin, a peptide derived from sortilin, studied for its potential role as an antagonist of the TREK-1 (TWIK-related potassium) channel. TREK-1 modulation is of significant interest in neurological research, particularly in models of depression, neurogenesis, and cognitive function.

Preclinical studies indicate that PE-22-28 may enhance neurogenesis and synaptogenesis in the hippocampus, potentially promoting neuronal growth, synaptic connectivity, and mood stabilization. The peptide has been reported to exhibit enhanced stability and rapid onset of action compared to native spadin, positioning it as a promising tool in research on depressive disorders, post-stroke depression, and nootropic effects.

Mechanism of Action:
PE-22-28 is believed to act as a TREK-1 receptor antagonist, modulating potassium ion flow in neurons and influencing neurotransmitter release. This inhibition may enhance neurogenic responses and support synaptic formation, contributing to its observed effects on mood and cognitive models.